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KMID : 0984720030350060365
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Infection and Chemotherapy
2003 Volume.35 No. 6 p.365 ~ p.369
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Antimicrobial Susceptibility of Escherichia coli and Klebsiella pneumoniae Blood Isolates over 5 Years
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Kang Cheol-In
Kim Dong-Min
Yi Jong-Youn
Park Wan-Beom
Lee Ki-Deok
Kim Hong-Bin
Oh Myoung-Don
Kim Eui-Chong
Choe Kang-Won
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Abstract
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Background : Escherichia coli and Klebsiella pneumoniae are major Gramnegative pathogens causing bloodstream infection. Antibioticresistant mutant strains that produce extendedspectrum betalactamase (ESBL) have emerged among E. coli and K. pneumoniae and are increasingly being recognized.
Methods : The database at the Clinical Microbiology Department was retrospectively reviewed in order to identify the patients with E. coli and K. pneumoniae bacteremia. The archived blood isolates of E. coli and K. pneumoniae, isolated and stored from Jan 1998 to Dec 2002, were tested for ESBL production using the NCCLS guidelines and/or doubledisk synergy test, and antimicrobial susceptibility by disk diffusion method using NSSCL guidelines.
Results : A total of 1045 strains of E. coli and 535 strains of K. pneumoniae were analyzed. The antimicrobial susceptibility of E. coli strains were as follows; cefotaxime 91%, ceftazidime 93%, imipenem 100%, amikacin 97%, gentamicin 75%, tobramycin 79%, and ciprofloxacin 75%. The antimicrobial susceptibility of K. pneumoniae strains were as follows; cefotaxime, 84%, ceftazidime, 87%, imipenem, 100%, amikacin, 94%, gentamicin, 87%, tobramycin, 84%, and ciprofloxacin, 87%. The overall prevalence of ESBLproducing organisms was 8.6% in E. coli and 14.2% in K. pneumoniae. In ESBLproducing organisms, all strains were susceptible to imipenem, whereas 40% of K. pneumoniae strains and 30% of E. coli strains were susceptible to ciprofloxacin.
Conclusion : The overall prevalence of ESBLproducing organisms was 8.6% in E. coli blood isolates and 14.2% in K. pneumoniae blood isolates. Among the ESBLproducing strains, only 40% of K. pneumoniae strains and 30% of E. coli strains were susceptible to ciprofloxacin.
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KEYWORD
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Escherichia coli, Klebsiella pneumoniae, Beta-lactamase, Antimicrobial drug resistance
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